ABSTRACT
Orthobiologics are biological materials that are intended for the regeneration of bone, cartilage, and soft tissues. In this review, we discuss the application of orthobiologics in Achilles tendinopathy, more specifically. We explain the concepts and definitions of each orthobiologic and the literature regarding its use in tendon disorders. The biological potential of these materials can be harnessed and administered into injured tissues, particularly in areas where standard healing is disrupted, a typical feature of Achilles tendinopathy. These products contain a wide variety of cell populations, cytokines, and growth factors, which have been shown to modulate many other cells at local and distal sites in the body. Collectively, they can shift the state of escalated inflammation and degeneration to reestablish tissue homeostasis. The typical features of Achilles tendinopathy are failed healing responses, persistent inflammation, and predominant catabolic reactions. Therefore, the application of orthobiologic tools represents a viable solution, considering their demonstrated efficacy, safety, and relatively easy manipulation. Perhaps a synergistic approach regarding the combination of these orthobiologics may promote more significant clinical outcomes rather than individual application. Although numerous optimistic results have been registered in the literature, additional studies and clinical trials are still highly desired to further illuminate the clinical utility and efficacy of these therapeutic strategies in the management of tendinopathies.
ABSTRACT
Some say that all diseases begin in the gut. Interestingly, this concept is actually quite old, since it is attributed to the Ancient Greek physician Hippocrates, who proposed the hypothesis nearly 2500 years ago. The continuous breakthroughs in modern medicine have transformed our classic understanding of the gastrointestinal tract (GIT) and human health. Although the gut microbiota (GMB) has proven to be a core component of human health under standard metabolic conditions, there is now also a strong link connecting the composition and function of the GMB to the development of numerous diseases, especially the ones of musculoskeletal nature. The symbiotic microbes that reside in the gastrointestinal tract are very sensitive to biochemical stimuli and may respond in many different ways depending on the nature of these biological signals. Certain variables such as nutrition and physical modulation can either enhance or disrupt the equilibrium between the various species of gut microbes. In fact, fat-rich diets can cause dysbiosis, which decreases the number of protective bacteria and compromises the integrity of the epithelial barrier in the GIT. Overgrowth of pathogenic microbes then release higher quantities of toxic metabolites into the circulatory system, especially the pro-inflammatory cytokines detected in osteoarthritis (OA), thereby promoting inflammation and the initiation of many disease processes throughout the body. Although many studies link OA with GMB perturbations, further research is still needed.
Subject(s)
Dysbiosis , Gastrointestinal Microbiome/immunology , Intestinal Mucosa , Osteoarthritis , Animals , Dysbiosis/immunology , Dysbiosis/microbiology , Humans , Intestinal Mucosa/immunology , Intestinal Mucosa/microbiology , Osteoarthritis/etiology , Osteoarthritis/immunology , Osteoarthritis/microbiologyABSTRACT
Os autores apresentam dois casos de fraturas instáveis da pelve em pacientes grávidas tratadas no Serviço de Ortopedia e Traumatologia da Santa Casa de Porto Alegre. A revisäo dsa literatura näo revelou descriçäo similar
Subject(s)
Humans , Female , Pregnancy , Adolescent , Adult , Sacroiliac Joint/surgery , Fractures, Bone/surgery , Pelvic Bones/surgery , Pubic Symphysis/surgery , Abortion, Spontaneous , Sacroiliac Joint/injuries , Sacroiliac Joint , Fracture Fixation , Fractures, Bone , Pelvic Bones/injuries , Pelvic Bones , Pubic Symphysis/injuries , Pubic SymphysisABSTRACT
Os autores apresentam dois casos de disjunçäo pós-traumática de sínfise púbica de longa evoluçäo. As pacientes näo foram submetidas a tratamento traumatológico e o espaço gerado pela diástase óssea ocasionou o aparecimento de grande hérnia abdominal que incluía útero, bexiga e alças intestinais
